PHF10 Is Required for Cell Proliferation in Normal and SV40-Immortalized Human Fibroblast Cells
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چکیده
منابع مشابه
PHF10 Is Required for Cell Proliferation in Normal and SV40-Immortalized Human Fibroblast Cells
Normal human diploid fibroblasts have limited life span in culture and undergo replicative senescence after 50-60 population doublings. On the contrary, cancer cells typically divide indefinitely and are immortal. Expression of SV40 large T and small t antigens in human fibroblasts transiently extends their life span by 20-30 population doublings and facilitates immortalization. We have identif...
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ژورنال
عنوان ژورنال: Cytogenetic and Genome Research
سال: 2009
ISSN: 1424-859X,1424-8581
DOI: 10.1159/000251960